INTRODUCTORY BROCHURE The DoseMe Platform The DoseMe® Platform Personalised Medicine: Making Complex Simple What is DoseMe®?DoseMe is an easy-to-use Bayesian dose-individualisation platform designed for clinicians and healthcare practitioners to optimise patient care. DoseMe currently supports several classes of drugs, including antibiotics, anti-coagulants, and
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Brecklandscientific.co.ukRevision date 08-04-2016 Section 1: Identification of the substance/ mixture and of the company/ undertaking.
1.1 Product identifier 1.2 Relevant identified uses of the substances or mixture and uses advised against Laboratory chemicals, manufacture of substances, Scientific R&D 1.3 Details of the supplier of the safety data sheet Breckland Scientific Supplies Ltd Antom Court, Tollgate Drive, Stafford, ST16 3AF Emergency telephone 08:30-17:00 01785 227227 Section 2: Hazards identification 2.1 Classification of the substance or mixture 2.1.1 Classification - Xn; R22 Acute Tox. 4 Harmful 2.1.2 Classification – EC 2.2 Label elements Revision date 08-04-2015 Hazard Pictograms Hazard statement H302: Harmful if swallowed. Precautionary statement P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Section 3: Composition/information on ingredients 67/548/EEC/1999/45/EC S No. EINECS No. 58-08-2 200-362-1 H302 S No. EINECS No. 58-08-2 200-362-1 Xn; R22 Acute Tox. 4 Section 4: First aid measures 4.1 Description of first aid measures Move the exposed person to fresh air. If breathing stops, provide artificial respiration. Rinse immediately with plenty of water for 15 minutes holding the eyelids open. Seek medical attention. Remove all contaminated clothes and footwear immediately unless stuck to skin. Wash off immediately with plenty of soap and water. Seek medical attention if irritation or symptoms persist. DO NOT INDUCE VOMITING. Never give anything by mouth to an unconscious person. Rinse mouth thoroughly. Seek medical attention. General information: If you feel unwell, seek medical advice (show the label where possible). Section 5: Firefighting measures Revision date 08-04-2015 5.1 Extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment 5.2 Special hazards arising from No data available substances or mixture 5.3 Advice for firefighters Wear suitable respiratory equipment when necessary Section 6: Accidental release measures Wear suitable protective clothing. Avoid breathing 6.1 Personal precaution, vapours, mist or gas. Avoid formation of dust. Ensure protective equipment and adequate ventilation of the working area. Evacuate emergency procedures personnel to a safe area. Prevent further spillage if safe. Do not allow product to enter 6.2 Environmental precautions Avoid raising dust. Sweep up. Transfer to suitable, labelled 6.3 Methods and materials for containments and cleaning up containers for disposal. Section 7: Handling and storage 7.1 Precautions for safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid formation of dust. Ensure adequate ventilation of the working area. 7.2 Conditions for safe storage Store in a cool, dry area. Keep container tightly closed. including any incompatibilities. Section 8: Exposure controls/ personal protection 8.1 Control parameters 8.1.1 Exposure limit values Long Term (8hr TWA) Short term (15min period STEL) CAS No: 58-08-2 ppm Revision date 08-04-2015 8.2 Exposure controls Appropriate engineering Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of the working day. Ensure adequate ventilation of the working area. Eye/ face protection Approved safety glasses. Face shield where appropriate. Skin/ hand protection Wear suitable protective clothing and gloves. Respiratory protection Where risk assessment shows it is necessary, use a dust mask type or breathing apparatus. Section 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties Melting point oC: Boiling point oC: No data available Relative density g/cm3: Chemical formula: C₈H₁₀N₄O₂ Molecular weight g/mol: Section 10: Stability and reactivity No data available 10.2 Chemical stability Stable under normal conditions 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials No data available 10.6 Hazardous decomposition products No data available Section 11: Toxicological information 11.1 Information on toxicological effects: Acute toxicity No data available Germ cell mutagenicity No data available No data available Reproductive toxicity No data available 11.4 Toxicological information Caffeine Oral Rat LD50 mg/kg: 367.7 Section 12: Ecological information Revision date 08-04-2015 Toxicity to daphnia and other aquatic vertebrates EC50 Daphnia magna: 182 (Water flea) mg/l - 48hr Section 13: Disposal considerations General information Dispose of in compliance with all local and national regulations. Disposal methods Contact a licensed waste disposal company. Dispose of this material and its container to hazardous or special waste collection point Section 14: Transport information 14.1. UN Number: 14.2 UN Proper shipping name: Caffeine 14.3. Transport hazard class(es): 8 14.4. Packing group: II 14.5 Environmental hazards: ADR/RID: no IMDG Marine pollutant: no IATA: no Section 15: Regulatory information 15.1 Safety, health and environmental regulations/ legislation specific for the substance or mixture Labelling according to Regulation (EC) No 1272/2008. Section 16: Other information 16.1: Other information Text of risk phrases in Section 3 Xn; R22 Acute Tox. 4 Harmful Harmful if swallowed. Revision date 08-04-2015 Text of hazard statements in Section 3 H302 Harmful if swallowed. 16.2 Further information The information supplied in this Safety Data Sheet is designed only as guidance for the safe use, storage and handling of the product. This information is correct to the best of our knowledge and belief at the date of publication however no guarantee is made to its accuracy. This information relates only to the specific material designated and may not be valid for such material used in combination with any other materials. Breckland Scientific Supplies Limited will not be held liable for any damage or injury caused by this product and does not obviate the requirement for end users to carry out their own workplace and specific use risk assessment.
Implantable Cardioverter-Defibrillator Efficacy in Patients With Heart Failure and Left Ventricular Dysfunction (from the MADIT II Population) Wojciech Zareba, MD, PhD, Katarzyna Piotrowicz, MD, Scott McNitt, MS, and Arthur J. Moss, MD, for the MADIT II Investigators The Multicenter Automatic Defibrillator Implantation The Multicenter Automatic Defibrillator Trial II