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Dr christine klipping

Publications dr Christine Klipping
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Articles
Oral follicle-stimulating hormone agonist tested in healthy young women of reproductive age failed to demonstrate effect on follicular development but affected thyroid function. Fertil Steril. 2016 Jan 6 [Epub ahead of print]. K Waellnitz, I Duijkers, C Klipping, T Rautenberg, B Rohde, C Zurth. A two-centre, open-label, randomised study of ovulation inhibition with three transdermal contraceptive patches, each containing different amounts of ethinyl oestradiol and gestodene in healthy, young women. J Obstet Gynaecol, Early Online 1-8, 19 Oct 2015. V Brache, L Cochon, IJM Duijkers, DP Levy, N Kapp, C Monteil, JL Abitbol, C Klipping. A prospective, randomized, pharmacodynamic study of quick-starting a desogestrel progestin-only pill following ulipristal acetate for emergency contraception. Hum Reprod Advance Access September 23, 2015. I.J.M. Duijkers, C. Klipping, Y. Zimmerman, N. Appels, M. Jost, C. Maillard, M. Mawet, J-M. Foidart, H.J.T. Coelingh Bennink. Inhibition of ovulation by administration of estetrol in combination with Drospirenone or levonorgestrel: Results of a phase II dose-finding pilot study. Eur J Contr Reprod Health Care 2015; 20; 476-489. M Mawet, C Maillard, C Klipping, Y Zimmerman, J-M Foidart, HJT Coelingh Bennink. Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives. Eur J Contrac Reprod Health Care, 2015; online: 1–13. ST Cameron, C Berger, L Michie, C Klipping, K Gemzell-Danielsson. The effects on ovarian activity of ulipristal acetate when ‘quickstarting' a combined oral contraceptive pill: a prospective, randomized, double-blind parallel-arm, placebo-controlled study. Hum Reprod 2015;30:1566-72. KD Cobey, AP Buunk, TV Pollet, C Klipping, S Craig Roberts. Men perceive their female partners and themselves, as more attractive around ovulation. Biol Psychol, 2013;94:513-516. J Endrikat, S Parke, D Trummer, M Serrani, I Duijkers, C Klipping. Pituitary, ovarian and additional contraceptive effects of an estradiol-based combined oral contraceptive: results of a randomized, open-label study. Contraception, 2013;87(2):227-34. Christine Klipping, Ingrid Duijkers, Michel P Fortier, Joachim Marr, Dietmar Trummer, Jörg Elliesen. Contraceptive efficacy and tolerability of ethinylestradiol 20 µg/drospirenone 3 mg in a flexible extended regimen: an open-label, multicentre, randomized, controlled study. J Fam Planning Reprod Health Care 38:73-83, 2012 Christine Klipping, Ingrid Duijkers, Michel P Fortier, Joachim Marr, Dietmar Trummer, Jörg Elliesen. Long-term tolerability of ethinylestradiol 20 µg/drospirenone 3 mg in a flexible extended regimen: results from a randomized, controlled, multicentre study. J Fam Planning Reprod Health Care 38:84-93, 2012 Hartmut Blode, Christine Klipping, Frank Richard, Dietmar Trummer, Beate Rohde, Konstanze Diefenbach. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception 85:178184,2012 Christine Klipping, Ingrid Duijkers, Ageeth Remmers, Thomas Faustmann, Christian Zurth, Stefan Klein, Barbara Schütt. Ovulation-inhibiting effects of dienogest in a randomized, dose-controlled pharmacodynamic trial of healthy women. J Clin Pharmacol, Epub 2011 Nov 29 Christine Klipping, Ingrid Duijkers, Susanne Parke, Uwe Mellinger, Marco Serrani, Wolfgang Junge. Hemostatic effects of a novel estradiol-based oral contraceptive: an open-label, randomized, crossover study of estradiol valerate/dienogest versus ethinylestradiol/levonorgestrel. Drugs RD 11:159-170, 2011 Leena Anttila, Gloria Bachmann, László Hernádi, Michael Kunz, Joachim Marr, Christine Klipping. Contraceptive efficacy of a combined oral contraceptive containing ethinyloestradiol 20 µg/drospirenone 3 mg administered in a 24/4 regimen: a pooled analysis of four open-label studies. Eur J Obstet Gynecol Reprod Biol 155:180-182, 2011 Ingrid JM Duijkers, Christine Klipping, Paul Grob, Tjeerd Korver. Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol. European Journal of Contraception and Reproductive Health Care, 15:314-325, 2010, Epub 2010 Aug 9 Ingrid JM Duijkers, Christine Klipping. Polycystic ovaries, as defined by the 2003 Rotterdam consensus criteria, are found to be very common in young healthy women. Gynaecological Endocrinology 26: 152-160, 2010. Epub 2009 Sep 15 Klipping C, Duijkers I, Trummer D, Marr J. Suppression of ovarian activity with a drospirenone-containing oral contraceptive in a 24/4 regimen. Contraception 78: 16-25, 2008 Endrikat J, Parke S, Trummer D, Schmidt W, Duijkers I, Klipping C. Ovulation inhibition with four variations of a four-phasic estradiol valerate/dienogest combined oral contraceptive: results of two prospective, randomized, open-label studies. Contraception 78: 218-25, 2008. Epub 2008 Jul 11 Hemelaar M, Kenemans P, Hack CE, Klipping C, van der Mooren MJ. Hemostatic markers in helathy postmenopausal women during intranasal and oral hormone therapy: a randomized trial. Menopause 15: 248-255, 2008 R Massai, L Mäkäräinen, A Kuukankorpi, C Klipping, I Duijkers, T Dieben. The combined contraceptive vaginal ring and bone mineral density in healthy pre-menopausal women. Human Reproduction 20:2764-2768, 2005 Christine Klipping, Joachim Marr. Effects of two combined oral contraceptives containing ethinyl estradiol 20 µg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. Contraception 71: 409-416, 2005 Ingrid JM Duijkers, Lonneke Engels, Christine Klipping. Length of the menstrual cycle after discontinuation of oral contraceptives. Gynecological Endocrinology 20: 74-79, 2005 Tjeerd Korver, Christine Klipping, Doris Heger-Mahn, Ingrid Duijkers, Gonnie van Osta, Thom Dieben. Maintenance of ovulation inhibition with the 75-µg desogestrel-only contraceptive pill (Cerazette®) after scheduled 12-h delays in tablet intake. Contraception, 71:8-13, 2005 D Heger-Mahn, C Warlimont, T Faustmann, C Gerkinger, C Klipping. Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers. European Journal of Contraception and Reproductive Health Care, 9:173-181, 2004 Ingrid JM Duijkers, Christine Klipping, Carole HJ Verhoeven, Thom OM Dieben. Ovarian function with the contraceptive vaginal ring (NuvaRing) or an oral contraceptive: a randomized study. Human Reproduction, 19: 2668-2673, 2004 Ingrid JM Duijkers, Carole HJ Verhoeven, Thom OM Dieben, Christine Klipping. Follicular growth during pill or ring treatment depends on the day of ovulation in the pre-treatment cycle. Human Reproduction, 19: 2674-2679, 2004 D Heger-Mahn, C Warlimont, T Faustmann, C Gerlinger, C Klipping. Combined ethinylestradiol/gestodene contrcaeptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers. The European Journal of Contraception and Reproductive Health Care, 9: 173-181, 2004 Ingrid JM Duijkers, Leoni A Louwé, Ddid DM Braat, Christine Klipping. One, two or three: how many directions are useful in transvaginal ultrasound measurement of ovarian follicles? European Journal of Obstetrics and Gynecology, 117: 60-63, 2004 Oral Contraceptive and Hemostasis Study Group. The effects of seven monophasic oral contraceptive regimens on hemostatic variables: conclusions from a large randomized multicenter study. Contraception 2003;67:173-185 Nagaraja NV, Pechstein B, Erb K, Klipping C, Hermann R, Locher M, Derendorf H. Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women. J Clin Pharmacol 2003;43:243-251 Ingrid J.M. Duijkers, Christine Klipping, Peter J. Boerrigter, Christel S.M. Machielsen, Joris J. de Bie and Gerrit Voortman. Single dose pharmacokinetics and effects on follicular growth and serum hormones of a long-acting recombinant FSH preparation (FSH-CTP) in healthy pituitary-suppressed females. Human Reproduction 2002;8:1987-1993 J. Endrikat, C. Klipping, M. Cronin, C.Gerlinger, A. Ruebig, W. Schmidt, B. Duesterberg. An open label, comparative study of the effects of a dose-reduced oral contraceptive containing 20mg ethinyl estradiol and 100mg levonorgestrel on hemostatic, lipids, and carbohydrate metabolism variables. Contraception 2002;65:215-221 J. Endrikat, C. Klipping, C.Gerlinger, A. Ruebig, W.Schmidt, T. Holler, B. Duesterberg. A double-blind comparative study of the effects of a 23-day oral contraceptive regimen with 20 mg ethinyl estradiol and 75 mg gestodene and a 21-day regimen with 30 mg ethinyl estradiol and 75 mg gestodene on hemostatic variables, lipids, and carbohydrate metabolism. Contraception 2001;64:235-241 Van Hoof HJ, de Sevaux RG, van Baelen H, Swinkels LM, Klipping C, Ross HA, Sweep CG. Relationship between free and total 1,25-dihydroxyvitamin D in condition of modified binding. Eur J Endocrinol 2001;144:391-396 Erb K, Klipping C, Duijkers I, Pechstein B, Schueler A, Hermann R. Pharmacodynamic
effects and plasma pharmacokinetics of single doses of cetrorelix acetate in healthy
premenopausal women. Fertility and Sterility, 75: 316-323, 2001
Duijkers IJM, Klipping C. Ultrasonographic assessment of endocervix and cervical mucus in
ovulatory menstrual cycles. Eur J Obstet Gynecol Reprod Biol, 93: 13-17, 2000
Nagaraja NV, Pechstein B, Erb K, Klipping C, Hermann R, Niebch G, Derendorf H.
Pharmacokinetic and pharmacodynamic modeling of cetrorelix, an LH-RH antagonist, after
subcutaneous administration in healthy premenopausal women. Clin Pharmacol Ther
2000;68:617-625
Oral Contraceptive and Hemostasis Study Group. An open label, randomized study to
evaluate the effects of seven monophasic oral contraceptive regimens on hemostatic
variables. Contraception 1999;59:345-355
Van der Mooren MJ, Klipping C, van Aken B, Helmerhorst E, Spielmann D, Kluft C. A
comparative study of the effects of gestodene 60 µg/ethinylestradiol 15 µg and desogestrel
150 µg/ethinylestradiol 20 µg on hemostatic balance, blood lipid levels and carbohydrate
metabolism. Eur J Contracept Reprod Health Care 1999;4 suppl 2:27-35
Duijkers IJM, Klipping C, Willemsen WNP, Krone D, Schneider E, Niebch G, Hermann R.
Single and multiple dose pharmacokinetics and pharmacodynamics of the gonadotrophin-
releasing hormone antagonist cetrorelix in healthy female volunteers. Human Reproduction
1998;13: 2392-2398
C. Klipping and D. Heger-Mahn. Discussion on early clinical drug development in the target
population with respect to the field of reproductive endocrinology. Int J Clin Pharm
1998;36:591-593
IJM Duijkers, C Klipping, TMT Mulders, HJ Out, HJT Coelingh Bennink, HM Vemer.
Pharmacodynamics and pharmacokinetics after repeated subcutaneous administration of
three gonadotrophin preparations. Human Reproduction 1997;12: 2379-2384
K Breithaupt-Grögler, D Heger-Mahn, C Klipping, R Butzer, I Duijkers, D Geyer, R Hermann,
C Hinze, M Mahler, M Seibert-Grafe, K Westermann. Klinische Arzneimittelprüfung an
Frauen. Überlegungen zum Thema Schwangerschaftsverhütung. Deutsches Ärzteblatt
1997;94: A-991-993
Hermann R, Heger-Mahn D, Mahler M, Seibert-Grafe M, Klipping C, Breithaupt Grögler K, de
Mey C. Adverse events and discomfort in studies on healthy subjects: the volunteer's
perspective. Eur J Clin Pharmacol 1997;53:207-214
Dibbelt L, Knuppen R, Jütting G, Heimann S, Klipping C, Parikka-Olexik H. Group
comparison of serum ethinylestradiol, SHBG and CBG levels in 83 women using two low-
dose combination oral contraceptives for three months. Contraception 1991;43:1-21

Abstracts

C Klipping, I Duijkers. Women in clinical trials – a training course. AGAH Workshop
Kontrazeption in Klinischen Prüfungen. Bonn, November 20, 2015.
C. Klipping. Detailed ovulation inhibition studies using E4 as the estrogen. 16th World
Congress on Human Reproduction, Berlin, March 20, 2015.
C Klipping. Is there an ideal study design for the development of hormonal contraceptives? Presentation AGAH Workshop "Hormonal contraceptives, development and their use in other trials in the fertile female population". October 11-12, 2013 C Klipping, I Duijkers, TA Faustmann, SF Klein, B Schuett. Ovulation-inhibiting effects of dienogest at clinically relevant doses in endometriosis treatment. Abstract 13th World Congress on controversies in Obstetrics, Gynecology & Infertility (COGI). Berlin, Germany, November 4-7, 2010. C Klipping, I Duijkers, TA Faustmann, SF Klein, B Schuett. Pharmacodynamic study of four oral dosages of dienogest. Abstract 66th annual meeting of the ASRM. Denver, USA, October 23-27, 2010. C Klipping, W Junge, U Mellinger, I Duijkers, A Machlitt, S Parke. Comparative effects of estradiol valerate/dienogest and ethinylestradiol/levonorgestrel on hemostatic parameters. Abstract 3rd Congress of Asia-Pacific Council on Contraception, Beijing, China, June 11-13.2010. IJM Duijkers, C Klipping, P Grob, T Korver. Endometrial and cervical mucus responses to a unique, monophasic combined oral contraceptive containing nomegestrol acetate/17 beta-estradiol. Abstract 14th World Congress of Gynecological Endocrinology, Florence, March 4-7, 2010. IJM Duijkers, C Klipping, P Grob, T Korver. Effects of a unique, monophasic combined oral contraceptive containing nomegestrol acetate/17 beta-estradiol on ovarian function. Abstract 14th World Congress of Gynecological Endocrinology, Florence, March 4-7, 2010. C Klipping, W Junge, U Mellinger, I Duijkers, S Parke. Haemostatic effects of a novel four-phasic combined oral contraceptive containing estradiol valerate and dienogest. Abstract ESC April 30-May2, 2008 J Endrikat, P Korner, C Klipping. Ovulation Inhibition with 4 Different Regimens of a 4-Phasic Estradiol Valerate and Dienogest OC. Abstract ACOG 2007 C Klipping, I Duijkers, D Trummer, J Marr. Decreased Ovarian Activity with a Shorter Pill-Free Interval with an Ethinylestradiol 20mcg Plus Drospirenone 3mg Oral Contraceptive. FIGO 2006. FC3.23.7 C Klipping, J Marr, P Korner. Ovulation inhibition effects of two low-dose oral contraceptive dosing regimens following intentional dosing errors. Abstract ACOG, Washington, May 2006. Obstet Gynecol 107:49S, 2006 C Klipping. Women in phase I studies: practical issues concerning inclusion of women in phase I studies. Presentation Joint Meeting of AGAH and Club Phase 1, Strassbourg, March 17 18, 2005. C Klipping. Studies in gynaecological endocrinology = the ideal area to learn about women in clinical trials. Presentation Annual Meeting of Club Phase 1, Paris, February 6, 2004. Duijkers I., Klipping C., Verhoeven C., Dieben T. NuvaRing suppresses ovarian function. Abstract 20th Meeting of the ESHRE, Berlin, June 28 - 30, 2004 Duijkers I., Klipping C., Boerrigter P., Machielsen C., de Bie J. and Voortman G.
Pharmacokinetics and -dynamics of long-acting recombinant FSH (FSH-CTP). Abstract 18th
Meeting of the ESHRE, Vienna, June 30 - July 3, 2002
I Duijkers, C Klipping, K Erb, B Pechstein, A Schueler, R Hermann. Effects on hormone
levels, ovulation and pharmacokinetics of single doses of cetrorelix in normal menstrual
cycles. Journal of Reproduction and Fertility 26: 4, 2000
K Erb, C Klipping, I Duijkers, B Pechstein, A Schueler, R Hermann. Pharmacodynamics and
pharmacokinetics of single subcutaneous doses of cetrorelix acetate (Cetrotide) in a
placebo-controlled study in healthy premenopausal women. Abstract 8th International
Society of Gynecological Endocrinology, Florence, December 6-9, 2000
IJM Duijkers, C Klipping, WNP Willemsen, D Krone, E Schneider, G Niebch, P Romeis, R
Hermann. Farmacokinetiek en farmacodynamiek van de GnRH-antagonist Cetrorelix bij
gezonde vrouwelijke vrijwilligers: eenmalige en dagelijkse toediening. Tijdschrift voor
Fertiliteitsonderzoek, 2: 59-60, 1999
Duijkers IJM, Klipping C, Willemsen WNP, Krone D, Schneider E, Niebch G, Romeis P,
Hermann R. Single and multiple dose pharmacokinetics and pharmacodynamics of the
gonadotrophin-releasing hormone antagonist Cetrorelix in healthy female volunteers.
Abstract 14th Meeting of the ESHRE, Göteborg, June 24, 1998
van der Mooren MJ, Klipping C, van Aken B, Helmerhorst FM, Spielman D, Kluft C. Effects of
a 24-day Regimen of Gestodene 60mg/Ethinyl Estradiol 15mg on Hemostatic Balance, Blood
Lipids, and Carbohydrate Metabolism. Abstract 5th Congress of the European Society of
Contraception, Prague, June 17-20, 1998
Klipping C, Duijkers IJM, Willemsen WNP, Ochs D, Schneider E, Hermann R. Single and
multiple dose pharmacokinetics and pharmacodynamics of the LH-RH-antagonist Cetrorelix
in healthy female volunteers. Abstract Xth World Congress on In Vitro Fertilization and
Assisted Reproduction, Vancouver, May 24-28, 1997
Duijkers IJM, Klipping C, Mulders TMT, Out HJ, Coelingh Bennink HJT, Pennings AMM,
Vemer HM. Follicular development after 7-day subcutaneous administration of Normegon,
Follegon and Metrodin-HP. Abstract 11th Meeting of the ESHRE, Hamburg, June 28 - July 1,
1995
Formation of catecholestrogens and catecholestrogenmethylethers in human follicles
G. Emons, C. Klipping, H.O. Knuppen, P. Ball, H. v.d.Ven, K. Diederich, M. Besanko,
16. Jahrestagung zum Studium der Fertilität und Sterilität, Bonn, 1987

Other publications

Arzneimittelprüfung als Bestandteil ärztlicher Tätigkeit. Breithaupt-Grögler K, Butzer R,
Heger-Mahn D, Klipping C, Mahler M
(AGAH-Broschüre 1998)
Patienteninformation und Einwilligungserklärung zur Teilnahme an klinischen Prüfungen
Breithaupt-Grögler K, Butzer R, Heger-Mahn D, Klipping C, Mahler M
(AGAH-Broschüre 1996)
Klinische Arzneimittelprüfung und Empfängnisverhütung, eine Informationsschrift für
Probandinnen. Breithaupt-Grögler K, Heger-Mahn D, Klipping C
(AGAH-Broschüre, 1994)

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