Hindawi Publishing CorporationISRN PharmacologyVolume 2014, Article ID 575423, 5 pageshttp://dx.doi.org/10.1155/2014/575423 Research ArticlePromotive Effect of Topical Ketoconazole, Minoxidil, andMinoxidil with Tretinoin on Hair Growth in Male Mice Muhsin A. Aldhalimi,1 Najah R. Hadi,2 and Fadaa A. Ghafil2 1 Department of Dermatology, Kufa College of Medicine, Kufa, Iraq2 Department of Pharmacology and Therapeutics, Kufa College of Medicine, Kufa, Iraq
Best Practices in Nursing
Care to Older Adults
From The Hartford Institute for Geriatric Nursing, New York University, College of Nursing, and the Alzheimer's Association Issue Number D8, Revised 2013 Editor-in-Chief: Sherry A. Greenberg, PhD(c) MSN, GNP-BC New York University College of Nursing Assessing and Managing Delirium in Older Adults with Dementia By: Donna Fick, PhD, APRN, BC, FGSA, FAAN, The Pennsylvania State University School of Nursing and Lorraine Mion, PhD, RN, FAAN, Vanderbilt University School of Nursing WHY: Delirium in a patient with pre-existing dementia is a common problem that may have life-threatening complications, especially if unrecognized and untreated. Acute changes in mental status in older adults with dementia are often missed, mislabeled, or mistakenly attributed to the underlying dementia or "sundowning."1 Delirium is thought to occur 4-5 times more often in a person with dementia. Delirium superimposed on dementia is less likely to be recognized and treated than is delirium without dementia. In patients with dementia, delirium can substantially worsen long-term outcomes, including prolonged hospitalization, further decline in cognitive and physical functioning, re-hospitalization, nursing home placement, and death.2-4 Delirium in older adults with dementia may be a sign of preventable and treatable medical problems or serious underlying illnesses such as a myocardial infarction, urinary tract infection, pneumonia, pain, or dehydration. Common medications causing delirium include diphenhydramine, benzodiazepines, anti-depressants, sedative-hypnotics, and anti-psychotics.5 An unrecognized delirium may interfere with recovery and rehabilitation after a hospitalization.3 BEST TOOLS: Delirium is difficult to assess in older adults with dementia and in hospitalized older adults due to overlapping features of delirium and dementia and the uncertainty of the patient's baseline mental status. Most tools to assess delirium are less specific when assessing delirium in older adults with dementia. Use a standardized tool to measure delirium, if possible, such as the Confusion Assessment Method (CAM)6 (See Try This: Confusion Assessment Method). The CAM focuses on the KEY FEATURES OF DELIRIUM: Acute onset and fluctuating course, inattention, disorganized thinking, and altered level of consciousness. The Delirium Superimposed on Dementia Algorithm suggested on page two recommends a process to assess for delirium for people with a pre-existing dementia. Poor attention is a key marker in delirium and delirium superimposed on dementia. Many of these tools can be integrated into the electronic medical record.7 TARGET POPULATION: The Delirium Superimposed on Dementia Algorithm should be used with any older adult with dementia who is hospitalized, at home, in assisted living, in the nursing home, or in the emergency room with a change in mental or physical functioning. All older adults with dementia, who experience an acute change in mental or physical functioning and/or behavior changes, should be assessed for delirium superimposed on the dementia.
STRENGTHS AND LIMITATIONS: While the CAM is a useful tool, the Delirium Superimposed on Dementia Algorithm recognizes that the patient's baseline mental status is a critical parameter for assessing and treating delirium. It recommends review of the patient's medical record for indications of pre-existing dementia, and checking with the patient's family, if any, as to whether the patient has a diagnosis of dementia or signs and symptoms of possible dementia. If a patient is admitted from an assisted living or long term care facility, the nurse should question the staff at the facility about the patient's baseline mental and functional status. The algorithm presents practical ways for bedside nurses to assess delirium and CAM features such as poor attention and fluctuation.
The algorithm can be used with patients with dementia who present to the hospital without previous medical evaluation, and/or family members who cannot describe the patient's mental status pre-hospitalization, who are at increased risk for undetected delirium. The algorithm helps address ageism, a significant barrier to detecting the presence of delirium, wherein clinicians attribute further cognitive loss or lethargy in a person with dementia as an inevitable fact of life for older adults. (See Try This: Recognition of Dementia in Hospitalized Older Adults).
FOLLOW-UP: The algorithm includes assessment of mental status and physical functioning on a daily basis. Communication amongst interdisciplinary team members across health care settings is crucial to the detection and treatment of delirium in older adults, especially during times of acuity and transition.
REFERENCES: Best practice information on care of older adults: www.ConsultGeriRN.org. The American Geriatrics Society (AGS) 2012 Beers Criteria Update Expert Panel. (2012). American Geriatrics Society (AGS) Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. JAGS. doi: 10.1111/j.1532-5415.2012.03923.x. Available online at http://www.
americangeriatrics.org/files/documents/beers/2012BeersCriteria_JAGS.pdf 1. Steis, M.R, & Fick, D.M. (2012). Delirium superimposed on dementia: Accuracy of nurse documentation. Journal of Gerontological Nursing, 38(1), 32-42.
2. Leslie, D.L., Marcantonio, E.R., Zhang, Y., Leo-Summers, L., & Inouye, S.K. (2008). One-year health care costs associated with delirium in the elderly population. Archives of Internal Medicine, 168(1), 27-32 3. Inouye, S.K. (2006). Delirium in older persons. NEJM, 354(11), 1157-1165. 4. Fong, T.G., Jones, R.N., Marcantonio, E.R., Tommet, D., Gross, A.L., Habtemariam, D., Schmitt, E., Yap, L., & Inouye, S.K. (2012). Adverse outcomes after hospitalization and delirium in persons with Alzheimer disease. Annals of Internal Medicine, 156(12), 848-856, W296.
5. Vigen, C.L., Mack, W.J., Keefe, R.S., Sano, M., Sultzer, D.L., Stroup, T.S., et al. (2011). Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: Outcomes from CATIE-AD. American Journal of Psychiatry, 168(8), 831-839.
6. Inouye, S., van Dyck, C., Alessi, C., Balkin, S., Siegal, A., & Horwitz, R. (1990). Clarifying confusion: The confusion assessment method. Annals of Internal Medicine, 113(12), 941-948. 7. Fick, D.M., Steis, M.R., Mion, L.C., & Walls, J.L. (2011). Computerized decision support for delirium superimposed on dementia. Journal of Gerontological Nursing, 37(4), 39-47 doi: 10.3928/00989134-20100930-01.
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Delirium Superimposed on Dementia Algorithm
Assess for pre-hospital cognitive function:
Review the patient's medical record for indications of pre-existing dementia and/or functional difficulties. Ask the patient's family, if any, whether the patient has a diagnosis of dementia or signs and symptoms of possible dementia. Ask about mental status in past 6 months to one year. If a patient is admitted from an assisted living or long term care facility, question the staff about the patient's baseline mental and functional status. Complete a tool, such as the Family Questionnaire, to help assess pre-hospital cognitive and functional abilities (See Try This: Recognition of Dementia in Hospitalized Older Adults). Assess for and identify delirium promptly:
Use an instrument, such as the Confusion Assessment Method (CAM), to identify delirium quickly and at the bedside (Inouye, 1990). Acute onset (acute meaning minutes, hours, shifts, days--up to 2 weeks) or any change in cognition (inattention, memory loss, disorientation, hallucinations, delusions) or any change in function. Acute change in behaviors such as verbal and/or physical aggression, resistance to care, and wandering (See Try This: Wandering in the Hospitalized Older Adult). Fluctuation of mental status (unusual or changing function). Inattention: Assess by asking to say Days of the Week backwards or spell WORLD backwards and by observing for problems focusing, staring off into space, or losing track of questions. Disorganized thinking: Assess by asking, "What would you do if your home or room were on fire?" Altered level of consciousness. Hyperactive or hypoalert. Remember lethargy, falling asleep, staring off into space, and decreased motor activity is NOT NORMAL in older adults with dementia. (See Try This: Confusion Assessment Method) Assess for physiologic causes and risk
factors for delirium:
Medication(s) (See AGS 2012 Beers Room near nurse's station Environmental stimuli as Criteria; Try This: Beers Criteria) (monitor for excessive noise Fecal impaction and stimulation due to Urinary retention Non-drug alternatives and Infection (urine, lungs, skin) Motion sensor alarm Asses fall risk (See Try Provide sensory aides This: Fall Risk Assessment) Cognitive stimulation Remove/camouflage tubes Hydration & nutrition Pain (See Try This: Assessing Pain) Use of increased activities/room (all about surveillance & rounding Sensory impairment Follow-up assessment
Educate the family about the nature of delirium, indicating this is not a "worsening of dementia" but an acute or emergent health issue. Do admission and discharge teaching. Continue to assess cognition using the CAM and observing behaviors. Continue with preventative strategies. Educate and counsel family regarding signs of re-occurrence and duration (2 weeks to 6 months) of delirium. A series provided by The Hartford Institute for Geriatric Nursing, Best Practices in Nursing
New York University, College of Nursing Care to Older Adults
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IJA-2016_1.qxp_Hrev_master 07/04/16 10:31 Pagina 35 Italian Journal of Agronomy 2016; volume 11:704 Molecular identification and artificial cultivation of a wild isolate of oyster mushroom in Albania Jordan Merkuri,1 Stefania Mirela Mang,2 Ippolito Camele,2 Magdalena Cara,1Gian Luigi Rana2 1Department of Plant Protection, Agricultural University of Tirana, Tirana, Albania; 2School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata,Potenza, Italy